Assay Detail
Binding
CHEMBL798357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit HIV-1 Reverse Transcriptase (RT) using an rC-dG template/primer
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.22 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78882 | — | — | 1 | 8.04 |
| CHEMBL81227 | — | — | 1 | 7.97 |
| CHEMBL79526 | — | — | 1 | 7.96 |
| CHEMBL309896 | — | — | 1 | 7.92 |
| CHEMBL82764 | — | — | 1 | 7.89 |
| CHEMBL80064 | — | — | 1 | 7.75 |
| CHEMBL268871 | L-697661 | — | 1 | 7.72 |
| CHEMBL314012 | — | — | 1 | 7.71 |
| CHEMBL311996 | — | — | 1 | 7.63 |
| CHEMBL309462 | — | — | 1 | 7.19 |
| CHEMBL79403 | — | — | 1 | 7.16 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.14 |
| CHEMBL310306 | — | — | 1 | 6.89 |
| CHEMBL82481 | — | — | 1 | 6.57 |
| CHEMBL79696 | — | — | 1 | 6.35 |
| CHEMBL309696 | — | — | 1 | 5.82 |
| CHEMBL311050 | — | — | 1 | 5.03 |
| CHEMBL82662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78882 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL81227 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL79526 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL309896 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL82764 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL80064 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL268871 | L-697661 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL314012 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL311996 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL309462 | — | IC50 | = | 64.5 | nM | 7.19 |
| CHEMBL79403 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL310306 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL82481 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL79696 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL309696 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL311050 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL82662 | — | IC50 | > | 10000.0 | nM | - |