Assay Detail
Binding
CHEMBL798385
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Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor alpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.83 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165843 | — | — | 1 | 7.52 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.62 |
| CHEMBL151870 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165843 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL38 | TRETINOIN | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL151870 | — | EC50 | = | 435.0 | nM | 6.36 |