Assay Detail
Functional
CHEMBL798412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 value was evaluated by measuring the inhibition of the 5-HT-induced contraction of rat aorta.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 23 | 7.65 | 9.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543613 | — | — | 1 | 9.87 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 9.16 |
| CHEMBL539544 | — | — | 1 | 9.13 |
| CHEMBL544091 | — | — | 1 | 9.02 |
| CHEMBL92673 | — | — | 1 | 8.92 |
| CHEMBL545727 | — | — | 1 | 8.13 |
| CHEMBL87717 | — | — | 1 | 8.12 |
| CHEMBL308480 | — | — | 1 | 7.86 |
| CHEMBL544319 | — | — | 1 | 7.82 |
| CHEMBL542428 | — | — | 1 | 7.79 |
| CHEMBL95112 | — | — | 1 | 7.63 |
| CHEMBL87943 | — | — | 1 | 7.47 |
| CHEMBL96781 | — | — | 1 | 7.35 |
| CHEMBL95098 | — | — | 1 | 7.30 |
| CHEMBL310734 | — | — | 1 | 7.27 |
| CHEMBL544089 | — | — | 1 | 7.20 |
| CHEMBL540822 | — | — | 1 | 6.95 |
| CHEMBL545488 | — | — | 1 | 6.83 |
| CHEMBL87026 | — | — | 1 | 6.75 |
| CHEMBL92145 | — | — | 1 | 6.72 |
| CHEMBL310153 | — | — | 1 | 6.48 |
| CHEMBL542181 | — | — | 1 | 6.21 |
| CHEMBL544318 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543613 | — | Kd | = | 0.1349 | nM | 9.87 |
| CHEMBL42 | CLOZAPINE | Kd | = | 0.6918 | nM | 9.16 |
| CHEMBL539544 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL544091 | — | Kd | = | 0.955 | nM | 9.02 |
| CHEMBL92673 | — | Kd | = | 1.202 | nM | 8.92 |
| CHEMBL545727 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL87717 | — | Kd | = | 7.586 | nM | 8.12 |
| CHEMBL308480 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL544319 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL542428 | — | Kd | = | 16.22 | nM | 7.79 |
| CHEMBL95112 | — | Kd | = | 23.44 | nM | 7.63 |
| CHEMBL87943 | — | Kd | = | 33.88 | nM | 7.47 |
| CHEMBL96781 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL95098 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL310734 | — | Kd | = | 53.7 | nM | 7.27 |
| CHEMBL544089 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL540822 | — | Kd | = | 112.2 | nM | 6.95 |
| CHEMBL545488 | — | Kd | = | 147.91 | nM | 6.83 |
| CHEMBL87026 | — | Kd | = | 177.83 | nM | 6.75 |
| CHEMBL92145 | — | Kd | = | 190.55 | nM | 6.72 |
| CHEMBL310153 | — | Kd | = | 331.13 | nM | 6.48 |
| CHEMBL542181 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL544318 | — | Kd | = | 1258.93 | nM | 5.90 |