Assay Detail
Functional
CHEMBL798530
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Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.36 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.70 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.75 |
| CHEMBL347478 | — | — | 1 | 6.31 |
| CHEMBL347429 | — | — | 1 | 6.12 |
| CHEMBL157550 | — | — | 1 | 6.02 |
| CHEMBL346928 | — | — | 1 | 6.00 |
| CHEMBL157897 | — | — | 1 | 4.63 |
| CHEMBL156054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL347478 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL347429 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL157550 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL346928 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL157897 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL156054 | — | IC50 | - | nM | - |