Assay Detail
Functional
CHEMBL798774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL4567) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and cyclic GMP phosphodiesterase inhibitory activity of a series of 6-phenylpyrazolo[3,4-d]pyrimidones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 55 | 6.41 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439923 | — | — | 1 | 7.70 |
| CHEMBL416267 | — | — | 1 | 7.52 |
| CHEMBL42988 | — | — | 1 | 7.40 |
| CHEMBL43862 | — | — | 1 | 7.40 |
| CHEMBL43443 | — | — | 1 | 7.40 |
| CHEMBL43225 | — | — | 1 | 7.30 |
| CHEMBL298295 | — | — | 1 | 7.30 |
| CHEMBL289701 | — | — | 1 | 7.22 |
| CHEMBL290402 | — | — | 1 | 7.00 |
| CHEMBL291178 | — | — | 1 | 7.00 |
| CHEMBL288061 | — | — | 1 | 6.82 |
| CHEMBL43205 | — | — | 1 | 6.70 |
| CHEMBL298294 | — | — | 1 | 6.70 |
| CHEMBL297763 | — | — | 1 | 6.70 |
| CHEMBL42680 | — | — | 1 | 6.70 |
| CHEMBL296071 | — | — | 1 | 6.70 |
| CHEMBL44467 | — | — | 1 | 6.70 |
| CHEMBL289344 | — | — | 1 | 6.52 |
| CHEMBL295613 | — | — | 1 | 6.52 |
| CHEMBL41004 | — | — | 1 | 6.52 |
| CHEMBL42779 | — | — | 1 | 6.52 |
| CHEMBL45367 | — | — | 1 | 6.46 |
| CHEMBL42796 | — | — | 1 | 6.46 |
| CHEMBL46621 | — | — | 1 | 6.40 |
| CHEMBL45039 | — | — | 1 | 6.35 |
| CHEMBL42435 | — | — | 1 | 6.16 |
| CHEMBL42172 | — | — | 1 | 6.05 |
| CHEMBL42886 | — | — | 1 | 6.05 |
| CHEMBL46693 | — | — | 1 | 6.00 |
| CHEMBL297864 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439923 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL416267 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL43862 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43443 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL42988 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43225 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL298295 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL289701 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL290402 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL291178 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL288061 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL297763 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL298294 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL43205 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL42680 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL296071 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL44467 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL289344 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL295613 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL41004 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL42779 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL45367 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL42796 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL46621 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL45039 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL42435 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL42886 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL42172 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL46693 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL297864 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL46416 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL46639 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL43320 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL46831 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL42776 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL47108 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL42570 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL42713 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL295796 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL42563 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL43795 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL42272 | — | EC50 | < | 100.0 | nM | - |
| CHEMBL44508 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL298478 | — | EC50 | < | 10.0 | nM | - |
| CHEMBL295329 | — | EC50 | < | 100.0 | nM | - |
| CHEMBL290694 | — | EC50 | < | 100.0 | nM | - |
| CHEMBL46771 | — | EC50 | < | 10.0 | nM | - |
| CHEMBL46714 | — | EC50 | < | 100.0 | nM | - |
| CHEMBL298282 | — | EC50 | < | 100.0 | nM | - |