Assay Detail
Binding
CHEMBL798911
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Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 7.37 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 9.40 |
| CHEMBL82716 | — | — | 1 | 8.96 |
| CHEMBL309282 | — | — | 1 | 8.92 |
| CHEMBL78587 | — | — | 1 | 8.77 |
| CHEMBL82609 | — | — | 1 | 7.37 |
| CHEMBL77961 | — | — | 1 | 7.30 |
| CHEMBL78835 | — | — | 1 | 6.60 |
| CHEMBL81273 | — | — | 1 | 6.28 |
| CHEMBL82089 | — | — | 1 | 6.17 |
| CHEMBL309469 | — | — | 1 | 5.89 |
| CHEMBL80992 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL82716 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL309282 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL78587 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL82609 | — | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL77961 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL78835 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL81273 | — | Kd | = | 531.0 | nM | 6.28 |
| CHEMBL82089 | — | Kd | = | 679.0 | nM | 6.17 |
| CHEMBL309469 | — | Kd | = | 1275.0 | nM | 5.89 |
| CHEMBL80992 | — | Kd | = | 4095.0 | nM | 5.39 |