Assay Detail
Binding
CHEMBL798924
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Inhibition of recombinant reverse transcriptase (RT) in cell-free Quan-T-RT assay system
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.85 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 6.22 |
| CHEMBL69952 | — | — | 1 | 6.22 |
| CHEMBL114559 | — | — | 1 | 6.16 |
| CHEMBL116474 | — | — | 1 | 6.10 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 6.10 |
| CHEMBL116350 | — | — | 1 | 6.05 |
| CHEMBL114598 | — | — | 1 | 5.92 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.82 |
| CHEMBL432812 | — | — | 1 | 5.31 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 4.64 |
| CHEMBL117524 | — | — | 1 | - |
| CHEMBL114652 | — | — | 1 | - |
| CHEMBL117182 | — | — | 1 | - |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39999 | TROVIRDINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL69952 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL114559 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL116474 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL116350 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL114598 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL432812 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL117524 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL114652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL117182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |