Assay Detail
Binding
CHEMBL798930
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Inhibition of [3H]targretin binding to Retinoid X receptor RXR alpha
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of the first retinoid X, receptor homodimer antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111589 | — | — | 1 | 8.70 |
| CHEMBL109847 | — | — | 1 | 8.40 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.10 |
| CHEMBL109581 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111589 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL109847 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL705 | ALITRETINOIN | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL109581 | — | Ki | = | 8.0 | nM | 8.10 |