Assay Detail
Binding
CHEMBL798931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 3[H]9-cis-retinoic acid binding to Retinoic acid receptor RXR-alpha expressed in CV-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of fluorinated RXR modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.68 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110195 | — | — | 1 | 8.42 |
| CHEMBL326673 | — | — | 1 | 8.32 |
| CHEMBL111217 | — | — | 1 | 8.11 |
| CHEMBL110921 | — | — | 1 | 8.09 |
| CHEMBL325592 | — | — | 1 | 7.97 |
| CHEMBL92050 | — | — | 1 | 7.94 |
| CHEMBL107555 | — | — | 1 | 7.30 |
| CHEMBL107554 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110195 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL326673 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL111217 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL110921 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL325592 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL92050 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL107555 | — | Ki | = | 50.3 | nM | 7.30 |
| CHEMBL107554 | — | Ki | = | 5208.0 | nM | 5.28 |