Assay Detail
Binding
CHEMBL798996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.99 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48427 | — | — | 1 | 5.65 |
| CHEMBL50019 | — | — | 1 | 5.55 |
| CHEMBL296589 | — | — | 1 | 5.54 |
| CHEMBL359315 | — | — | 1 | 5.54 |
| CHEMBL151152 | — | — | 1 | 5.38 |
| CHEMBL150025 | — | — | 1 | 5.38 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 4.84 |
| CHEMBL346225 | — | — | 1 | 4.37 |
| CHEMBL357261 | — | — | 1 | 4.25 |
| CHEMBL357713 | — | — | 1 | 4.21 |
| CHEMBL150149 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48427 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL50019 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL296589 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL359315 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL151152 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL150025 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL625 | THIABENDAZOLE | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL346225 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL357261 | — | IC50 | = | 56600.0 | nM | 4.25 |
| CHEMBL357713 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL150149 | — | IC50 | = | 67000.0 | nM | 4.17 |