Assay Detail
Binding
CHEMBL799136
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The compound was evaluated for the inhibition of HIV-1 reverse transcriptase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.17 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57995 | — | — | 1 | 7.75 |
| CHEMBL283619 | — | — | 1 | 7.51 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.33 |
| CHEMBL58596 | — | — | 1 | 6.86 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 6.38 |
| CHEMBL58865 | — | — | 1 | 5.33 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.31 |
| CHEMBL299935 | — | — | 1 | 4.61 |
| CHEMBL58552 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57995 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL283619 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL58596 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL929 | DELAVIRDINE MESYLATE | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL58865 | — | IC50 | = | 4627.0 | nM | 5.33 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 4848.0 | nM | 5.31 |
| CHEMBL299935 | — | IC50 | = | 24667.0 | nM | 4.61 |
| CHEMBL58552 | — | IC50 | = | 35870.0 | nM | 4.45 |