Assay Detail
Binding
CHEMBL799138
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Inhibition of HIV-1 reverse transcriptase (RT)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.89 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336237 | — | — | 1 | 7.82 |
| CHEMBL416107 | — | — | 1 | 7.52 |
| CHEMBL140532 | — | — | 1 | 7.00 |
| CHEMBL341931 | — | — | 1 | 6.40 |
| CHEMBL37067 | — | — | 1 | 6.40 |
| CHEMBL357409 | — | — | 1 | 6.22 |
| CHEMBL140048 | — | — | 1 | - |
| CHEMBL126931 | — | — | 1 | - |
| CHEMBL341880 | — | — | 1 | - |
| CHEMBL31871 | HEPT | — | 1 | - |
| CHEMBL142098 | — | — | 1 | - |
| CHEMBL356674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336237 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL416107 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL140532 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL341931 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL37067 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL357409 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL140048 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL126931 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL341880 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL31871 | HEPT | IC50 | > | 6000.0 | nM | - |
| CHEMBL142098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL356674 | — | IC50 | > | 10000.0 | nM | - |