Assay Detail
Binding
CHEMBL799142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The quantity of compound required to reduce WT Reverse transcriptase activity by 50%
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.41 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 6.30 |
| CHEMBL58607 | — | — | 1 | 5.80 |
| CHEMBL57772 | — | — | 1 | 4.80 |
| CHEMBL132691 | — | — | 1 | 4.73 |
| CHEMBL293961 | — | — | 1 | - |
| CHEMBL58581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL58607 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL57772 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL132691 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL293961 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL58581 | — | IC50 | = | 110000.0 | nM | - |