Assay Detail
Binding
CHEMBL799143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.19 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.96 |
| CHEMBL3143101 | — | — | 1 | 7.70 |
| CHEMBL3143102 | — | — | 1 | 7.16 |
| CHEMBL2112687 | — | — | 1 | 4.92 |
| CHEMBL473686 | — | — | 1 | 4.92 |
| CHEMBL2111874 | — | — | 1 | 4.50 |
| CHEMBL2112691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3143101 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3143102 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2112687 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL473686 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2111874 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2112691 | — | IC50 | > | 100000.0 | nM | - |