Assay Detail
Binding
CHEMBL799565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation of Retinoid X receptor RXR alpha
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.30 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116886 | — | — | 1 | 7.27 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.00 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.05 |
| CHEMBL118268 | — | — | 1 | 5.64 |
| CHEMBL118307 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116886 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL38 | TRETINOIN | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL118268 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL118307 | — | EC50 | = | 2800.0 | nM | 5.55 |