Assay Detail
Binding
CHEMBL799665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for Retinoic acid receptor RAR beta
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.42 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.15 |
| CHEMBL144058 | — | — | 1 | 4.68 |
| CHEMBL357015 | — | — | 1 | - |
| CHEMBL92096 | — | — | 1 | - |
| CHEMBL344122 | — | — | 1 | - |
| CHEMBL147845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL144058 | — | Kd | = | 21000.0 | nM | 4.68 |
| CHEMBL357015 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL92096 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL344122 | — | Kd | > | 3000.0 | nM | - |
| CHEMBL147845 | — | Kd | > | 30000.0 | nM | - |