Assay Detail
Binding
CHEMBL799719
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Binding affinity towards retinoic acid receptor alpha was determined using [3H]ATRA (5 nM) as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.12 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.85 |
| CHEMBL358145 | — | — | 1 | 7.77 |
| CHEMBL165843 | — | — | 1 | 7.44 |
| CHEMBL350485 | — | — | 1 | 6.89 |
| CHEMBL349935 | — | — | 1 | 6.87 |
| CHEMBL151870 | — | — | 1 | 6.87 |
| CHEMBL349018 | — | — | 1 | 6.83 |
| CHEMBL424190 | — | — | 1 | 6.46 |
| CHEMBL164176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL358145 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL165843 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL350485 | — | Kd | = | 129.0 | nM | 6.89 |
| CHEMBL349935 | — | Kd | = | 136.0 | nM | 6.87 |
| CHEMBL151870 | — | Kd | = | 135.0 | nM | 6.87 |
| CHEMBL349018 | — | Kd | = | 148.0 | nM | 6.83 |
| CHEMBL424190 | — | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL164176 | — | Kd | > | 1000.0 | nM | - |