Assay Detail
Binding
CHEMBL799791
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Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses and structure-activity relationships of 5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.95 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134375 | — | — | 1 | 9.35 |
| CHEMBL69367 | — | — | 1 | 7.39 |
| CHEMBL25202 | TAMIBAROTENE | 4.0 | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134375 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL69367 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL25202 | TAMIBAROTENE | IC50 | = | 78.0 | nM | 7.11 |