Assay Detail
Binding
CHEMBL799803
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Binding affinity towards Retinoic acid receptor alpha
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activities of new heterocyclic aromatic retinoids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.97 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75848 | — | — | 1 | 6.31 |
| CHEMBL25361 | — | — | 1 | 6.24 |
| CHEMBL75732 | — | — | 1 | 6.12 |
| CHEMBL75048 | — | — | 1 | 6.09 |
| CHEMBL1265 | ADAPALENE | 4.0 | 1 | 5.96 |
| CHEMBL308170 | — | — | 1 | 5.83 |
| CHEMBL75527 | — | — | 1 | 5.24 |
| CHEMBL75311 | — | — | 1 | - |
| CHEMBL74218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75848 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL25361 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL75732 | — | Ki | = | 764.0 | nM | 6.12 |
| CHEMBL75048 | — | Ki | = | 821.0 | nM | 6.09 |
| CHEMBL1265 | ADAPALENE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL308170 | — | Ki | = | 1471.0 | nM | 5.83 |
| CHEMBL75527 | — | Ki | = | 5787.0 | nM | 5.24 |
| CHEMBL75311 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL74218 | — | Ki | > | 3000.0 | nM | - |