Assay Detail
Functional
CHEMBL799828
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Tested in vitro for inhibitory activity against plasma renin in rat models
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent renin inhibitory peptides containing hydrophilic end groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.33 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412950 | — | — | 1 | 9.59 |
| CHEMBL177904 | — | — | 1 | 9.59 |
| CHEMBL415615 | — | — | 1 | 9.48 |
| CHEMBL429882 | — | — | 1 | 9.48 |
| CHEMBL414795 | — | — | 1 | 9.31 |
| CHEMBL410067 | — | — | 1 | 9.24 |
| CHEMBL263257 | — | — | 1 | 8.96 |
| CHEMBL265833 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412950 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL177904 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL415615 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL429882 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL414795 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL410067 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL263257 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL265833 | — | IC50 | = | 1.1 | nM | 8.96 |