Assay Detail
Functional
CHEMBL799869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor alpha
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.71 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358145 | — | — | 1 | 7.51 |
| CHEMBL349018 | — | — | 1 | 6.68 |
| CHEMBL349935 | — | — | 1 | 6.66 |
| CHEMBL350485 | — | — | 1 | 6.65 |
| CHEMBL424190 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358145 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL349018 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL349935 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL350485 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL424190 | — | IC50 | = | 875.0 | nM | 6.06 |