Assay Detail
Functional
CHEMBL799889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of inhibitory concentration against bone resorption
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 7.65 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 9.62 |
| CHEMBL100827 | — | — | 1 | 9.21 |
| CHEMBL56073 | — | — | 1 | 8.98 |
| CHEMBL301247 | — | — | 1 | 8.96 |
| CHEMBL101886 | — | — | 1 | 8.89 |
| CHEMBL101472 | — | — | 1 | 8.84 |
| CHEMBL101230 | — | — | 1 | 8.78 |
| CHEMBL100508 | — | — | 1 | 8.74 |
| CHEMBL101207 | — | — | 1 | 8.71 |
| CHEMBL54537 | — | — | 1 | 8.59 |
| CHEMBL55464 | — | — | 1 | 8.57 |
| CHEMBL98476 | — | — | 1 | 8.57 |
| CHEMBL316913 | — | — | 1 | 8.55 |
| CHEMBL101407 | — | — | 1 | 8.51 |
| CHEMBL316844 | — | — | 1 | 8.49 |
| CHEMBL100441 | — | — | 1 | 8.41 |
| CHEMBL301244 | — | — | 1 | 8.41 |
| CHEMBL53982 | — | — | 1 | 8.40 |
| CHEMBL319519 | — | — | 1 | 8.39 |
| CHEMBL100835 | — | — | 1 | 8.37 |
| CHEMBL100830 | — | — | 1 | 8.32 |
| CHEMBL98703 | — | — | 1 | 8.30 |
| CHEMBL100335 | — | — | 1 | 8.29 |
| CHEMBL317646 | — | — | 1 | 8.29 |
| CHEMBL100295 | — | — | 1 | 8.21 |
| CHEMBL101539 | — | — | 1 | 8.15 |
| CHEMBL316663 | — | — | 1 | 8.00 |
| CHEMBL318071 | — | — | 1 | 7.98 |
| CHEMBL97911 | — | — | 1 | 7.75 |
| CHEMBL102209 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 0.2399 | nM | 9.62 |
| CHEMBL100827 | — | IC50 | = | 0.618 | nM | 9.21 |
| CHEMBL56073 | — | IC50 | = | 1.047 | nM | 8.98 |
| CHEMBL301247 | — | IC50 | = | 1.102 | nM | 8.96 |
| CHEMBL101886 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL101472 | — | IC50 | = | 1.445 | nM | 8.84 |
| CHEMBL101230 | — | IC50 | = | 1.66 | nM | 8.78 |
| CHEMBL100508 | — | IC50 | = | 1.816 | nM | 8.74 |
| CHEMBL101207 | — | IC50 | = | 1.972 | nM | 8.71 |
| CHEMBL54537 | — | IC50 | = | 2.594 | nM | 8.59 |
| CHEMBL55464 | — | IC50 | = | 2.692 | nM | 8.57 |
| CHEMBL98476 | — | IC50 | = | 2.692 | nM | 8.57 |
| CHEMBL316913 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL101407 | — | IC50 | = | 3.119 | nM | 8.51 |
| CHEMBL316844 | — | IC50 | = | 3.251 | nM | 8.49 |
| CHEMBL100441 | — | IC50 | = | 3.89 | nM | 8.41 |
| CHEMBL301244 | — | IC50 | = | 3.917 | nM | 8.41 |
| CHEMBL53982 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL319519 | — | IC50 | = | 4.074 | nM | 8.39 |
| CHEMBL100835 | — | IC50 | = | 4.266 | nM | 8.37 |
| CHEMBL100830 | — | IC50 | = | 4.819 | nM | 8.32 |
| CHEMBL98703 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL100335 | — | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL317646 | — | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL100295 | — | IC50 | = | 6.152 | nM | 8.21 |
| CHEMBL101539 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL316663 | — | IC50 | = | 10.07 | nM | 8.00 |
| CHEMBL318071 | — | IC50 | = | 10.47 | nM | 7.98 |
| CHEMBL97911 | — | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL102209 | — | IC50 | = | 17.99 | nM | 7.75 |
| CHEMBL100232 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL100831 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL323300 | — | IC50 | = | 18.45 | nM | 7.73 |
| CHEMBL318861 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL321075 | — | IC50 | = | 39.36 | nM | 7.41 |
| CHEMBL102185 | — | IC50 | = | 49.43 | nM | 7.31 |
| CHEMBL323299 | — | IC50 | = | 50.82 | nM | 7.29 |
| CHEMBL273286 | — | IC50 | = | 55.85 | nM | 7.25 |
| CHEMBL98787 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL98211 | — | IC50 | = | 66.68 | nM | 7.18 |
| CHEMBL101717 | — | IC50 | = | 72.11 | nM | 7.14 |
| CHEMBL101647 | — | IC50 | = | 157.4 | nM | 6.80 |
| CHEMBL318504 | — | IC50 | = | 185.35 | nM | 6.73 |
| CHEMBL101716 | — | IC50 | = | 246.04 | nM | 6.61 |
| CHEMBL293116 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL327756 | — | IC50 | = | 599.79 | nM | 6.22 |
| CHEMBL98080 | — | IC50 | = | 632.41 | nM | 6.20 |
| CHEMBL98629 | — | IC50 | = | 732.82 | nM | 6.13 |
| CHEMBL98083 | — | IC50 | = | 885.12 | nM | 6.05 |
| CHEMBL97920 | — | IC50 | = | 1174.9 | nM | 5.93 |