Assay Detail
Binding
CHEMBL800043
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Inhibitory concentration for 50% inhibition of HIV-1 reverse transcriptase
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.63 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300087 | — | — | 2 | 7.35 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.32 |
| CHEMBL49316 | — | — | 1 | 6.97 |
| CHEMBL48628 | — | — | 1 | 6.96 |
| CHEMBL297897 | — | — | 1 | 6.92 |
| CHEMBL295606 | — | — | 1 | 6.91 |
| CHEMBL48376 | — | — | 1 | 6.91 |
| CHEMBL299394 | — | — | 1 | 6.90 |
| CHEMBL50550 | — | — | 2 | 6.90 |
| CHEMBL431936 | — | — | 1 | 6.89 |
| CHEMBL299978 | — | — | 1 | 6.83 |
| CHEMBL295893 | — | — | 1 | 6.80 |
| CHEMBL297851 | — | — | 1 | 6.80 |
| CHEMBL50664 | — | — | 1 | 6.77 |
| CHEMBL301370 | OPAVIRALINE | 2.0 | 1 | 6.75 |
| CHEMBL49733 | — | — | 1 | 6.74 |
| CHEMBL299073 | — | — | 1 | 6.58 |
| CHEMBL46008 | — | — | 1 | 6.50 |
| CHEMBL49531 | — | — | 1 | 6.48 |
| CHEMBL48286 | — | — | 1 | 6.47 |
| CHEMBL300721 | — | — | 1 | 6.39 |
| CHEMBL297103 | — | — | 1 | 6.30 |
| CHEMBL46209 | — | — | 1 | 6.22 |
| CHEMBL48629 | — | — | 1 | 6.19 |
| CHEMBL301986 | — | — | 1 | 6.17 |
| CHEMBL439929 | — | — | 1 | 5.94 |
| CHEMBL301996 | — | — | 1 | 5.74 |
| CHEMBL49030 | — | — | 1 | 5.74 |
| CHEMBL295567 | — | — | 1 | - |
| CHEMBL48735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300087 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL49316 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL48628 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL300087 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL297897 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL295606 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL48376 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL50550 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL299394 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL431936 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL299978 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL295893 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL297851 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL50664 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL301370 | OPAVIRALINE | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL49733 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL50550 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL299073 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL46008 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL49531 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL48286 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL300721 | — | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL297103 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL46209 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL48629 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL301986 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL439929 | — | IC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL301996 | — | IC50 | = | 1818.0 | nM | 5.74 |
| CHEMBL49030 | — | IC50 | = | 1807.0 | nM | 5.74 |
| CHEMBL295567 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL48735 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL299788 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL48255 | — | IC50 | > | 5000.0 | nM | - |