Assay Detail
Binding
CHEMBL800328
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In vitro binding affinity for Retinoic acid receptor RAR alpha
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.72 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.80 |
| CHEMBL357015 | — | — | 1 | 6.00 |
| CHEMBL92096 | — | — | 1 | 5.22 |
| CHEMBL344122 | — | — | 1 | 5.05 |
| CHEMBL144058 | — | — | 1 | 4.55 |
| CHEMBL147845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL357015 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL92096 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL344122 | — | Kd | = | 9000.0 | nM | 5.05 |
| CHEMBL144058 | — | Kd | = | 28000.0 | nM | 4.55 |
| CHEMBL147845 | — | Kd | > | 5000.0 | nM | - |