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Assay Detail

CHEMBL800466

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against retinoic acid receptor beta by [3H]ATRA displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Retinoic acid receptor RXR-beta (CHEMBL4047)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design, synthesis and structure-activity relationship of novel RXR-selective modulators.
Michellys PY, D'Arrigo J, Grese TA, Karanewsky DS, Leibowitz MD, Mais DA, Mapes CM, Reifel-Miller A, Rungta D, Boehm MF.
Bioorg Med Chem Lett (2004) 14 : 1593 -1598
PubMed 15006411 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.31 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39206 1 5.57
CHEMBL288436 1 5.45
CHEMBL417520 1 5.24
CHEMBL41890 1 5.23
CHEMBL41675 1 5.04
CHEMBL2372524 1 -
CHEMBL41260 1 -
CHEMBL43238 1 -
CHEMBL290399 1 -
CHEMBL41422 1 -
CHEMBL44420 1 -
CHEMBL41146 1 -
CHEMBL42314 1 -
CHEMBL290761 1 -
CHEMBL41742 1 -
CHEMBL290246 1 -
CHEMBL265051 1 -
CHEMBL289057 1 -
CHEMBL291034 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39206 Ki = 2700.0 nM 5.57
CHEMBL288436 Ki = 3515.0 nM 5.45
CHEMBL417520 Ki = 5736.0 nM 5.24
CHEMBL41890 Ki = 5940.0 nM 5.23
CHEMBL41675 Ki = 9200.0 nM 5.04
CHEMBL2372524 Ki > 10000.0 nM -
CHEMBL41260 Ki > 10000.0 nM -
CHEMBL43238 Ki > 10000.0 nM -
CHEMBL290399 Ki > 10000.0 nM -
CHEMBL41422 Ki > 10000.0 nM -
CHEMBL44420 Ki > 10000.0 nM -
CHEMBL41146 Ki > 10000.0 nM -
CHEMBL42314 Ki > 1000.0 nM -
CHEMBL290761 Ki > 10000.0 nM -
CHEMBL41742 Ki > 10000.0 nM -
CHEMBL290246 Ki > 10000.0 nM -
CHEMBL265051 Ki > 10000.0 nM -
CHEMBL289057 Ki > 10000.0 nM -
CHEMBL291034 Ki > 10000.0 nM -