Assay Detail
Binding
CHEMBL800472
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor alpha
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.14 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41890 | — | — | 1 | 7.70 |
| CHEMBL44420 | — | — | 1 | 7.41 |
| CHEMBL289057 | — | — | 1 | 7.13 |
| CHEMBL2372524 | — | — | 1 | 7.07 |
| CHEMBL417520 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41890 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL44420 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL289057 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2372524 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL417520 | — | EC50 | = | 390.0 | nM | 6.41 |