Assay Detail
Binding
CHEMBL800520
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Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.90 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 8.42 |
| CHEMBL296880 | — | — | 1 | 7.05 |
| CHEMBL49908 | — | — | 1 | 6.96 |
| CHEMBL45537 | — | — | 1 | 6.90 |
| CHEMBL49511 | — | — | 1 | 6.80 |
| CHEMBL50600 | — | — | 1 | 6.78 |
| CHEMBL415930 | — | — | 1 | 6.77 |
| CHEMBL49737 | — | — | 1 | 6.70 |
| CHEMBL416457 | — | — | 1 | 6.70 |
| CHEMBL49917 | — | — | 1 | 6.48 |
| CHEMBL295729 | — | — | 1 | 6.30 |
| CHEMBL1794978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL296880 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL49908 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL45537 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL49511 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL50600 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL415930 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL49737 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL416457 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL49917 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL295729 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1794978 | — | Ki | > | 1000.0 | nM | - |