Assay Detail
Functional
CHEMBL800545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Retinoic acid receptor RXR-alpha agonist activity in vitro
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90824 | — | — | 1 | 8.70 |
| CHEMBL88740 | — | — | 1 | 8.70 |
| CHEMBL92430 | — | — | 1 | 8.15 |
| CHEMBL288436 | — | — | 1 | 7.96 |
| CHEMBL92050 | — | — | 1 | 7.75 |
| CHEMBL329334 | — | — | 1 | 7.44 |
| CHEMBL91185 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90824 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL88740 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL92430 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL288436 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL92050 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL329334 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL91185 | — | EC50 | = | 506.0 | nM | 6.30 |