Assay Detail
Binding
CHEMBL800579
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Inhibitory activity against HIV rRT activity in wild type IIIB strain
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.08 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150424 | — | — | 1 | 6.57 |
| CHEMBL299714 | — | — | 1 | 6.40 |
| CHEMBL356611 | — | — | 1 | 6.40 |
| CHEMBL151896 | — | — | 1 | 6.35 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.22 |
| CHEMBL79403 | — | — | 1 | 6.05 |
| CHEMBL149275 | — | — | 1 | 6.05 |
| CHEMBL151411 | — | — | 1 | 5.40 |
| CHEMBL151077 | — | — | 1 | 5.30 |
| CHEMBL148764 | — | — | 1 | - |
| CHEMBL151620 | — | — | 1 | - |
| CHEMBL146981 | — | — | 1 | - |
| CHEMBL357327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150424 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL299714 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL356611 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL151896 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL79403 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL149275 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL151411 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL151077 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL148764 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL151620 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL146981 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL357327 | — | IC50 | > | 20000.0 | nM | - |