Assay Detail
Binding
CHEMBL800583
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Inhibitory activity against HIV-1 reverse transcriptase (RT)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.92 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99235 | — | — | 1 | 8.02 |
| CHEMBL268871 | L-697661 | — | 1 | 7.72 |
| CHEMBL37803 | — | — | 1 | 7.70 |
| CHEMBL83622 | — | — | 1 | 7.66 |
| CHEMBL329720 | — | — | 1 | 7.64 |
| CHEMBL83825 | — | — | 1 | 7.52 |
| CHEMBL99992 | — | — | 1 | 7.26 |
| CHEMBL98159 | — | — | 1 | 7.11 |
| CHEMBL99018 | — | — | 1 | 6.90 |
| CHEMBL415320 | — | — | 1 | 6.68 |
| CHEMBL316785 | — | — | 1 | 6.63 |
| CHEMBL431274 | — | — | 1 | 6.46 |
| CHEMBL95426 | — | — | 1 | 6.43 |
| CHEMBL318730 | — | — | 1 | 6.36 |
| CHEMBL82439 | — | — | 1 | 5.43 |
| CHEMBL98394 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99235 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL268871 | L-697661 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL37803 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL83622 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL329720 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL83825 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL99992 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL98159 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL99018 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL415320 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL316785 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL431274 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL95426 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL318730 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL82439 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL98394 | — | IC50 | = | 6400.0 | nM | 5.19 |