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Assay Detail

CHEMBL800593

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn.
Patil AD, Freyer AJ, Eggleston DS, Haltiwanger RC, Bean MF, Taylor PB, Caranfa MJ, Breen AL, Bartus HR, Johnson RK.
J Med Chem (1993) 36 : 4131 -4138
PubMed 7506311 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.33 7.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL337029 1 7.42
CHEMBL422798 1 6.89
CHEMBL293498 1 6.16
CHEMBL134227 1 6.14
CHEMBL134252 1 5.05
CHEMBL334946 1 5.00
CHEMBL341394 1 4.96
CHEMBL132692 1 4.52
CHEMBL334861 1 4.34
CHEMBL335955 1 4.16
CHEMBL336955 1 4.00
CHEMBL133575 1 -
CHEMBL134236 1 -
CHEMBL132827 1 -
CHEMBL132986 1 -
CHEMBL129992 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL337029 IC50 = 38.0 nM 7.42
CHEMBL422798 IC50 = 130.0 nM 6.89
CHEMBL293498 IC50 = 700.0 nM 6.16
CHEMBL134227 IC50 = 720.0 nM 6.14
CHEMBL134252 IC50 = 9000.0 nM 5.05
CHEMBL334946 IC50 = 10000.0 nM 5.00
CHEMBL341394 IC50 = 11000.0 nM 4.96
CHEMBL132692 IC50 = 30000.0 nM 4.52
CHEMBL334861 IC50 = 46000.0 nM 4.34
CHEMBL335955 IC50 = 70000.0 nM 4.16
CHEMBL336955 IC50 = 100000.0 nM 4.00
CHEMBL133575 IC50 > 100000.0 nM -
CHEMBL134236 IC50 > 100000.0 nM -
CHEMBL132827 IC50 > 100000.0 nM -
CHEMBL132986 IC50 > 100000.0 nM -
CHEMBL129992 IC50 > 100000.0 nM -