Assay Detail
Binding
CHEMBL800602
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Tested for the inhibition of wild type HIV-1 (IIIB) RT
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.98 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253186 | — | — | 1 | 9.00 |
| CHEMBL88677 | — | — | 1 | 9.00 |
| CHEMBL135380 | — | — | 1 | 9.00 |
| CHEMBL132756 | — | — | 1 | 9.00 |
| CHEMBL436177 | — | — | 1 | 8.70 |
| CHEMBL436376 | — | — | 1 | 8.70 |
| CHEMBL103706 | — | — | 1 | 8.70 |
| CHEMBL341201 | — | — | 1 | 8.70 |
| CHEMBL435600 | — | — | 1 | 8.52 |
| CHEMBL133195 | — | — | 1 | 8.52 |
| CHEMBL334983 | — | — | 1 | 8.52 |
| CHEMBL252964 | — | — | 1 | 8.40 |
| CHEMBL134630 | — | — | 1 | 8.40 |
| CHEMBL253169 | — | — | 1 | 8.40 |
| CHEMBL399503 | — | — | 1 | 8.30 |
| CHEMBL402265 | — | — | 1 | 8.30 |
| CHEMBL429488 | — | — | 1 | 8.30 |
| CHEMBL253822 | — | — | 1 | 8.30 |
| CHEMBL135254 | — | — | 1 | 8.30 |
| CHEMBL135259 | — | — | 1 | 8.30 |
| CHEMBL398890 | — | — | 1 | 8.22 |
| CHEMBL253170 | — | — | 1 | 8.22 |
| CHEMBL253369 | — | — | 1 | 8.22 |
| CHEMBL443063 | — | — | 1 | 8.15 |
| CHEMBL137111 | — | — | 1 | 8.15 |
| CHEMBL252963 | — | — | 1 | 8.10 |
| CHEMBL253171 | — | — | 1 | 8.10 |
| CHEMBL135808 | — | — | 1 | 8.10 |
| CHEMBL319224 | — | — | 1 | 8.05 |
| CHEMBL398891 | THIOUREA, N-(5-BROMO-2-PYRIDINYL)-N'-(2-(2-CHLORO-3-ETHOXY-6-FLUOROPHENYL)ETHYL)- | 2.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253186 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL132756 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL135380 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL88677 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL436177 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL436376 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL103706 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL341201 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL435600 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL334983 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL133195 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL253169 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL134630 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL252964 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL135259 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL402265 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL135254 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL253822 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL429488 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL399503 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL398890 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL253170 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL253369 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL443063 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL137111 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL252963 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL253171 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL135808 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL319224 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL398891 | THIOUREA, N-(5-BROMO-2-PYRIDINYL)-N'-(2-(2-CHLORO-3-ETHOXY-6-FLUOROPHENYL)ETHYL)- | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL39999 | TROVIRDINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL99896 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL398837 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL135509 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL317574 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL116350 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL400708 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL135760 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL335202 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL135804 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL135179 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL268871 | L-697661 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL135662 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL254237 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL135235 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL133250 | — | IC50 | = | 320.0 | nM | 6.50 |