Assay Detail
Functional
CHEMBL800654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for agonistic activity in CV-1 cells expressing RXR-alpha
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cercopithecidae |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of benzofused heterocyclic RXR modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88740 | — | — | 1 | 8.70 |
| CHEMBL430651 | — | — | 1 | 7.19 |
| CHEMBL91979 | — | — | 1 | 6.63 |
| CHEMBL314745 | — | — | 1 | 6.04 |
| CHEMBL328507 | — | — | 1 | 5.99 |
| CHEMBL420808 | — | — | 1 | 5.84 |
| CHEMBL93571 | — | — | 1 | 5.84 |
| CHEMBL414218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88740 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL430651 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL91979 | — | EC50 | = | 235.0 | nM | 6.63 |
| CHEMBL314745 | — | EC50 | = | 914.0 | nM | 6.04 |
| CHEMBL328507 | — | EC50 | = | 1024.0 | nM | 5.99 |
| CHEMBL420808 | — | EC50 | = | 1442.0 | nM | 5.84 |
| CHEMBL93571 | — | EC50 | = | 1438.0 | nM | 5.84 |
| CHEMBL414218 | — | EC50 | - | nM | - |