Assay Detail
Binding
CHEMBL800662
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Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primer
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.65 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336635 | — | — | 1 | 7.21 |
| CHEMBL336807 | — | — | 1 | 7.01 |
| CHEMBL132770 | — | — | 1 | 6.89 |
| CHEMBL132491 | — | — | 1 | 6.85 |
| CHEMBL134106 | — | — | 1 | 6.85 |
| CHEMBL331330 | — | — | 1 | 6.60 |
| CHEMBL130177 | — | — | 1 | 6.60 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 6.58 |
| CHEMBL132883 | — | — | 1 | 6.57 |
| CHEMBL336318 | — | — | 1 | 6.39 |
| CHEMBL127283 | — | — | 1 | 6.37 |
| CHEMBL124338 | — | — | 1 | 6.30 |
| CHEMBL133469 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336635 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL336807 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL132770 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL132491 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL134106 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL331330 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL130177 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL132883 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL336318 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL127283 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL124338 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL133469 | — | IC50 | = | 510.0 | nM | 6.29 |