Assay Detail
Binding
CHEMBL800663
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Inhibition of Reverse transcriptase (Y181C) using poly(rA)600:oligo(dT)10 as template primer.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.75 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127283 | — | — | 1 | 6.41 |
| CHEMBL331330 | — | — | 1 | 6.40 |
| CHEMBL336807 | — | — | 1 | 6.37 |
| CHEMBL132883 | — | — | 1 | 6.35 |
| CHEMBL134106 | — | — | 1 | 6.08 |
| CHEMBL336318 | — | — | 1 | 6.06 |
| CHEMBL132770 | — | — | 1 | 6.04 |
| CHEMBL124338 | — | — | 1 | 5.96 |
| CHEMBL336635 | — | — | 1 | 5.70 |
| CHEMBL133469 | — | — | 1 | 5.58 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.08 |
| CHEMBL132491 | — | — | 1 | 4.96 |
| CHEMBL442696 | — | — | 1 | 4.82 |
| CHEMBL130177 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127283 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL331330 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL336807 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL132883 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL134106 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL336318 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL132770 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL124338 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL336635 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL133469 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL132491 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL442696 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL130177 | — | IC50 | = | 21000.0 | nM | 4.68 |