Assay Detail
Binding
CHEMBL800733
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In vitro inhibitory activity against human SDH
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Sorbitol dehydrogenase inhibitors (SDIs): a new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]piperazine-1-sulfonic acid dimethylamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.81 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90344 | — | — | 1 | 7.57 |
| CHEMBL91846 | — | — | 1 | 6.76 |
| CHEMBL90488 | — | — | 1 | 6.61 |
| CHEMBL330334 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90344 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL91846 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL90488 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL330334 | — | IC50 | = | 486.0 | nM | 6.31 |