Assay Detail
Binding
CHEMBL800746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory concentration against HIV-1 non-nucleoside reverse transcriptase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.03 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283619 | — | — | 1 | 7.51 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.33 |
| CHEMBL68137 | — | — | 1 | 7.27 |
| CHEMBL66947 | — | — | 1 | 7.16 |
| CHEMBL303446 | — | — | 1 | 7.05 |
| CHEMBL69005 | — | — | 1 | 6.91 |
| CHEMBL305996 | — | — | 1 | 6.86 |
| CHEMBL304938 | — | — | 1 | 6.84 |
| CHEMBL70077 | — | — | 1 | 6.76 |
| CHEMBL68353 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283619 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL68137 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL66947 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL303446 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL69005 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL305996 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL304938 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL70077 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL68353 | — | IC50 | = | 244.0 | nM | 6.61 |