Assay Detail
Binding
CHEMBL800747
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Tested for inhibitory concentration on HIV-1 Reverse transcriptase in the presence of poly(c)-oligo-(dG)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.02 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338047 | — | — | 1 | 7.70 |
| CHEMBL416107 | — | — | 1 | 7.52 |
| CHEMBL128931 | — | — | 1 | 7.00 |
| CHEMBL57733 | — | — | 1 | 7.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.70 |
| CHEMBL338936 | — | — | 1 | 6.70 |
| CHEMBL37067 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338047 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL416107 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL128931 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57733 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL338936 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL37067 | — | IC50 | = | 300.0 | nM | 6.52 |