Assay Detail
Binding
CHEMBL800921
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.05 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115713 | — | — | 1 | 10.00 |
| CHEMBL118860 | — | — | 2 | 9.70 |
| CHEMBL117130 | — | — | 1 | 9.52 |
| CHEMBL119349 | — | — | 1 | 8.96 |
| CHEMBL432809 | — | — | 1 | 8.70 |
| CHEMBL334213 | — | — | 1 | 8.64 |
| CHEMBL118265 | — | — | 1 | 8.60 |
| CHEMBL119233 | — | — | 1 | 8.28 |
| CHEMBL325193 | — | — | 1 | 8.20 |
| CHEMBL117973 | — | — | 1 | 8.18 |
| CHEMBL115738 | — | — | 1 | 8.15 |
| CHEMBL432632 | — | — | 1 | 8.11 |
| CHEMBL325198 | — | — | 1 | 8.08 |
| CHEMBL1160958 | — | — | 1 | 7.92 |
| CHEMBL116140 | — | — | 1 | 7.85 |
| CHEMBL117031 | — | — | 1 | 7.82 |
| CHEMBL119110 | — | — | 1 | 7.72 |
| CHEMBL118068 | — | — | 1 | 7.66 |
| CHEMBL119760 | — | — | 1 | 7.60 |
| CHEMBL119562 | — | — | 1 | 7.52 |
| CHEMBL424254 | — | — | 1 | 7.39 |
| CHEMBL119516 | — | — | 1 | 7.36 |
| CHEMBL334144 | — | — | 1 | 7.07 |
| CHEMBL421234 | — | — | 1 | 6.82 |
| CHEMBL119257 | — | — | 1 | 6.44 |
| CHEMBL117569 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115713 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL118860 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL117130 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL118860 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL119349 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL432809 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL334213 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL118265 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL119233 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL325193 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL117973 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL115738 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL432632 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL325198 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL1160958 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL116140 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL117031 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL119110 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL118068 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL119760 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL119562 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL424254 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL119516 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL334144 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL421234 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL119257 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL117569 | — | IC50 | = | 1600.0 | nM | 5.80 |