Assay Detail
Binding
CHEMBL800922
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Binding affinity to human sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.89 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118860 | — | — | 1 | 9.70 |
| CHEMBL119413 | — | — | 1 | 9.52 |
| CHEMBL333335 | — | — | 1 | 9.52 |
| CHEMBL441826 | — | — | 1 | 9.40 |
| CHEMBL119354 | — | — | 1 | 9.40 |
| CHEMBL119440 | — | — | 1 | 9.40 |
| CHEMBL119382 | — | — | 1 | 9.30 |
| CHEMBL331054 | — | — | 1 | 9.30 |
| CHEMBL323617 | — | — | 1 | 9.30 |
| CHEMBL119256 | — | — | 1 | 9.22 |
| CHEMBL119116 | — | — | 1 | 9.22 |
| CHEMBL119873 | — | — | 1 | 9.15 |
| CHEMBL116981 | — | — | 1 | 9.05 |
| CHEMBL115970 | — | — | 1 | 9.05 |
| CHEMBL118815 | — | — | 1 | 8.92 |
| CHEMBL332667 | — | — | 1 | 8.89 |
| CHEMBL332373 | — | — | 1 | 8.82 |
| CHEMBL118508 | — | — | 1 | 8.72 |
| CHEMBL432813 | — | — | 1 | 8.64 |
| CHEMBL117403 | — | — | 1 | 8.64 |
| CHEMBL117715 | — | — | 1 | 8.62 |
| CHEMBL324820 | — | — | 1 | 8.60 |
| CHEMBL117723 | — | — | 1 | 8.39 |
| CHEMBL325247 | — | — | 1 | 8.14 |
| CHEMBL118783 | — | — | 1 | 7.89 |
| CHEMBL119239 | — | — | 1 | 7.85 |
| CHEMBL117007 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118860 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL119413 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL333335 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL441826 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL119354 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL119440 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL119382 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL331054 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL323617 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL119256 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL119116 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL119873 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL116981 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL115970 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL118815 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL332667 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL332373 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL118508 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL432813 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL117403 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL117715 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL324820 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL117723 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL325247 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL118783 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL119239 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL117007 | — | IC50 | = | 32.0 | nM | 7.50 |