Assay Detail
Binding
CHEMBL800928
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In vitro inhibition of mutant Y181C recombinant reverse transcriptase of HIV-1 IIIB
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.97 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122343 | — | — | 1 | 6.55 |
| CHEMBL125203 | — | — | 1 | 6.43 |
| CHEMBL331330 | — | — | 1 | 6.40 |
| CHEMBL331911 | — | — | 1 | 6.39 |
| CHEMBL126107 | — | — | 1 | 6.35 |
| CHEMBL340453 | — | — | 1 | 6.32 |
| CHEMBL331790 | — | — | 1 | 6.31 |
| CHEMBL124610 | — | — | 1 | 6.28 |
| CHEMBL340822 | — | — | 1 | 6.21 |
| CHEMBL125478 | — | — | 1 | 6.21 |
| CHEMBL122460 | — | — | 1 | 6.18 |
| CHEMBL330990 | — | — | 1 | 6.14 |
| CHEMBL332675 | — | — | 1 | 6.11 |
| CHEMBL339406 | — | — | 1 | 6.11 |
| CHEMBL125019 | — | — | 1 | 6.10 |
| CHEMBL339279 | — | — | 1 | 6.07 |
| CHEMBL127456 | — | — | 1 | 6.06 |
| CHEMBL127283 | — | — | 1 | 6.06 |
| CHEMBL436392 | — | — | 1 | 6.03 |
| CHEMBL125715 | — | — | 1 | 6.02 |
| CHEMBL123478 | — | — | 1 | 5.97 |
| CHEMBL125112 | — | — | 1 | 5.96 |
| CHEMBL124338 | — | — | 1 | 5.96 |
| CHEMBL262633 | — | — | 1 | 5.91 |
| CHEMBL121881 | — | — | 1 | 5.88 |
| CHEMBL125437 | — | — | 1 | 5.80 |
| CHEMBL125896 | — | — | 1 | 5.74 |
| CHEMBL331684 | — | — | 1 | 5.68 |
| CHEMBL121827 | — | — | 1 | 5.67 |
| CHEMBL421246 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122343 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL125203 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL331330 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL331911 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL126107 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL340453 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL331790 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL124610 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL340822 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL125478 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL122460 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL330990 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL332675 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL339406 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL125019 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL339279 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL127456 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL127283 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL436392 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL125715 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL123478 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL125112 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL124338 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL262633 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL121881 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL125437 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL125896 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL331684 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL121827 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL421246 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL125324 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL340193 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL340403 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL340556 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL929 | DELAVIRDINE MESYLATE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL929 | DELAVIRDINE MESYLATE | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 60000.0 | nM | - |
| CHEMBL268871 | L-697661 | IC50 | > | 60000.0 | nM | - |
| CHEMBL7264 | ATEVIRDINE SULPHATE | IC50 | > | 60000.0 | nM | - |