Assay Detail
Binding
CHEMBL800983
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Inhibitory concentration against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by triplicate assay at high (~1 pfu/cell) multiplicity of injection (moi)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.77 |
| CHEMBL305612 | — | — | 1 | 4.70 |
| CHEMBL306257 | SYNGUANOL | — | 1 | - |
| CHEMBL75956 | — | — | 1 | - |
| CHEMBL74478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL305612 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL306257 | SYNGUANOL | IC50 | > | 30000.0 | nM | - |
| CHEMBL75956 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL74478 | — | IC50 | > | 100000.0 | nM | - |