Assay Detail
Binding
CHEMBL801066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of purified Human kidney renin (250 pg/mL) incubated with angiotensinogen at pH 7.2
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of some transition-state inhibitors of human renin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.17 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53139 | — | — | 3 | 8.70 |
| CHEMBL52833 | — | — | 1 | 8.70 |
| CHEMBL291787 | — | — | 1 | 8.40 |
| CHEMBL52929 | — | — | 1 | 8.40 |
| CHEMBL292812 | — | — | 1 | 8.22 |
| CHEMBL55787 | — | — | 1 | 8.15 |
| CHEMBL407670 | — | — | 1 | 8.00 |
| CHEMBL435178 | — | — | 1 | 7.82 |
| CHEMBL54655 | — | — | 1 | 7.70 |
| CHEMBL52395 | — | — | 1 | 7.70 |
| CHEMBL54322 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53139 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL52833 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL53139 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL291787 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL52929 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL292812 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL55787 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL53139 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL407670 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL435178 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL54655 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL52395 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54322 | — | IC50 | = | 20.0 | nM | 7.70 |