Assay Detail
Functional
CHEMBL801101
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Inhibition of human colon carcinoma SW-620 cell proliferation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.59 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61257 | — | — | 1 | 5.60 |
| CHEMBL56983 | — | — | 1 | 5.58 |
| CHEMBL57347 | — | — | 1 | - |
| CHEMBL45827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61257 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL56983 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL57347 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL45827 | — | IC50 | > | 25000.0 | nM | - |