Assay Detail
Functional
CHEMBL801129
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Inhibitory concentration required for antitumor activity against SBC-5 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SBC-5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of a novel class of cdc25A inhibitors from vitamin D3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.26 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157936 | — | — | 1 | 4.38 |
| CHEMBL332036 | — | — | 1 | 4.33 |
| CHEMBL345921 | — | — | 1 | 4.16 |
| CHEMBL155993 | — | — | 1 | 4.15 |
| CHEMBL158314 | — | — | 1 | - |
| CHEMBL156968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157936 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL332036 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL345921 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL155993 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL158314 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL156968 | — | IC50 | > | 100000.0 | nM | - |