Assay Detail
Functional
CHEMBL801182
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Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.14 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.28 |
| CHEMBL104004 | — | — | 1 | 6.77 |
| CHEMBL327096 | — | — | 1 | 6.68 |
| CHEMBL123024 | — | — | 1 | 6.40 |
| CHEMBL104900 | — | — | 1 | 6.40 |
| CHEMBL105362 | — | — | 1 | 6.38 |
| CHEMBL125371 | — | — | 1 | 6.21 |
| CHEMBL126010 | — | — | 1 | 6.00 |
| CHEMBL125180 | — | — | 1 | 5.62 |
| CHEMBL340343 | — | — | 1 | 5.13 |
| CHEMBL124605 | — | — | 1 | 5.13 |
| CHEMBL121823 | — | — | 1 | 4.67 |
| CHEMBL436589 | ACRIDONE | — | 1 | - |
| CHEMBL122057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL104004 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL327096 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL123024 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL104900 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL105362 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL125371 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL126010 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL125180 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL340343 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL124605 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL121823 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL436589 | ACRIDONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL122057 | — | IC50 | > | 100000.0 | nM | - |