Assay Detail
Functional
CHEMBL801183
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Cytotoxicity activity was measured in human ovarian cell line SKOV-3 using sulforhodamine B (SRB) assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.45 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423017 | — | — | 1 | 5.70 |
| CHEMBL90901 | — | — | 1 | 5.66 |
| CHEMBL92265 | — | — | 1 | 5.53 |
| CHEMBL89250 | — | — | 1 | 5.43 |
| CHEMBL91398 | — | — | 1 | 5.40 |
| CHEMBL89977 | — | — | 1 | 5.38 |
| CHEMBL329863 | — | — | 1 | 5.33 |
| CHEMBL91163 | — | — | 1 | 5.14 |
| CHEMBL91898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423017 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL90901 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL92265 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL89250 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL91398 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL89977 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL329863 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL91163 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL91898 | — | IC50 | > | 100000.0 | nM | - |