Assay Detail
Binding
CHEMBL801327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against TIBO-resistant HIV-1 RT Nucleic Acid polymerase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.88 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 5.00 |
| CHEMBL282382 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL282382 | — | IC50 | = | 17600.0 | nM | 4.75 |