Assay Detail
Functional
CHEMBL801564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Calcium mobilization in saponin permeabilised SH-SY5Y neuroblastoma cells at a pH of 6.8
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The novel Ins(1,4,5)P3 analogue 3-amino-3-deoxy-Ins(1,4,5)P3: a pH-dependent Ins(1,4,5)P3 receptor partial agonist in SH-SY5Y neuroblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.76 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160022 | — | — | 1 | 6.59 |
| CHEMBL1161529 | — | — | 1 | 5.43 |
| CHEMBL1161531 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160022 | — | EC50 | = | 255.0 | nM | 6.59 |
| CHEMBL1161529 | — | EC50 | = | 3676.0 | nM | 5.43 |
| CHEMBL1161531 | — | EC50 | = | 5315.0 | nM | 5.27 |