Assay Detail
Binding
CHEMBL801569
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Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR gamma
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.77 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89241 | — | — | 2 | 8.72 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.73 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89241 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL38 | TRETINOIN | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL705 | ALITRETINOIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL89241 | — | Ki | = | 124.0 | nM | 6.91 |